Abstract: To predict the action mechanism of Paeoniae Radix Alba against schistosomiasis and liver fibrosis by means of network pharmacology, active components of Paeoniae Radix Alba and their corresponding targets were screened by TCMSP database, targets related to schistosomiasis and liver fibrosis were retrieved through GeneCards database, drug-component-target-disease network was constructed by Cytoscape 3.8.2 software, and the protein-protein interaction network was constructed by STRING database. GO and KEGG enrichment analysis of drug-disease targets were performed using R language. Totally 13 active components of Paeoniae Radix Alba were screened out, 16 Paeoniae Radix Alba against schistosomiasis and liver fibrosis related targets were obtained, and the PPI network contained 15 proteins, including JUN, PTGS2, CAT, etc. The pathways of Paeoniae Radix Alba against schistosomiasis and liver fibrosis mainly include lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway and NF-kappa B signaling pathway. To preliminarily predict the mechanism of Paeoniae Radix Alba against schistosomiasis and liver fibrosis can provide new ideas and theoretical basis for further study.

Key words: Network pharmacology, Paeoniae Radix Alba, Schistosomiasis, Liver fibrosis, Mechanism