Abstract: In this study, network pharmacology was used to predict the mechanism of Gui Fu Li Zhong Pill （GFLZW） in the treatment of gastritis. Active compounds of GFLZW were screened from the TCMSP database. Targets for acute gastritis （AG） and chronic gastritis （CG） were collected from the GeneCards and OMIM databases. A “traditional Chinese medicine-compound-target-disease-pathway” network was constructed using Cytoscape 3.10.3. The STRING database was used to build a protein-protein interaction （PPI） network for 59 active compounds from six herbs in GFLZW and 131 common targets of AG/CG. GO and KEGG enrichment analyses were then performed. GFLZW exerts therapeutic effects on AG and CG mainly through active compounds such as isoliquiritigenin and DIBP （acting on targets including PTGS1, Nos2 and CA6） and through pathways such as metabolic pathways, neuroactive ligand-receptor interaction as well as through pathways in cancer. This study provides a preliminary prediction of the mechanism of GFLZW in gastritis and offers new ideas on and a theoretical basis for further research.

Key words: network pharmacology, Gui Fu Li Zhong Pill （GFLZW）, acute gastritis （AG）, chronic gastritis （CG）, mechanism of action