网络药理学探究桂附理中丸治疗胃炎机制的研究

楚雄师范学院学报 ›› 2026, Vol. 41 ›› Issue (3): 126-143.

网络药理学探究桂附理中丸治疗胃炎机制的研究

邱玺融¹, 朱朋艳², 田月³, 罗言春², 解智慧^4,*

1.楚雄师范学院学生处,云南楚雄 675000;
2.楚雄师范学院农学院,云南楚雄 675000;
3.永善县码口镇卫生院,云南永善 657300;
4.中共楚雄师范学院委员会统战部,云南楚雄 675000

收稿日期:2026-02-26 出版日期:2026-05-20 发布日期:2026-07-22
通讯作者: ^*解智慧（1982-）,女,博士后,副教授,研究方向为疾病靶标及作用机制。
作者简介:邱玺融（1998-）,女,助教,研究方向为网络药理学及疾病靶标。
基金资助:
楚雄师范学院博士科研启动项目（No. BSQD2425）

Research on the Mechanism of Gui Fu Li Zhong Pill in Treating Gastritis through Network Pharmacology

Qiu Xirong¹, Zhu Pengyan², Tian Yue³, Luo Yanchun², Xie Zhihui^4,*

1. Student Affairs Office, Chuxiong Normal University, Chuxiong, Yunnan Province 675000, China;
2. College of Agronomy, Chuxiong Normal University, Chuxiong, Yunnan Province 675000, China;
3. Health Center of Makou Township, Yongshan County, Zhaotong, Yunnan Province 657300, China;
4. United Front Work Department, Chuxiong Normal University, Chuxiong, Yunnan Province 675000, China

Received:2026-02-26 Online:2026-05-20 Published:2026-07-22

摘要/Abstract

摘要： 运用网络药理学方法预测桂附理中丸（Guifu Lizhong Pill, GFLZW）治疗胃炎的作用机制。通过TCMSP数据库对GFLZW药物活性成分进行筛选,通过GeneCards、OMIM数据库分别检索AG和CG的靶标,利用Cytoscape 3.10.3软件构建“中药-成分-靶点-疾病-信号通路”图,利用STRING数据库构建GFLZW 6种中药的59个活性成分与急性胃炎/慢性胃炎的131个共同靶标PPI互作网络并进行GO和KEGG信号通路富集分析。GFLZW主要通过异甘草素和DIBP等活性成分作用于PTGS1、Nos2、CA6等靶标及代谢通路、神经活性配体-受体相互作用、癌症通路等信号通路起到对AG和CG的治疗效果。初步预测GFLZW治疗胃炎的作用机制,为其深入研究提供新思路及理论依据。

关键词: 网络药理学, 桂附理中丸, 急性胃炎, 慢性胃炎, 作用机制

Abstract: In this study, network pharmacology was used to predict the mechanism of Gui Fu Li Zhong Pill （GFLZW） in the treatment of gastritis. Active compounds of GFLZW were screened from the TCMSP database. Targets for acute gastritis （AG） and chronic gastritis （CG） were collected from the GeneCards and OMIM databases. A “traditional Chinese medicine-compound-target-disease-pathway” network was constructed using Cytoscape 3.10.3. The STRING database was used to build a protein-protein interaction （PPI） network for 59 active compounds from six herbs in GFLZW and 131 common targets of AG/CG. GO and KEGG enrichment analyses were then performed. GFLZW exerts therapeutic effects on AG and CG mainly through active compounds such as isoliquiritigenin and DIBP （acting on targets including PTGS1, Nos2 and CA6） and through pathways such as metabolic pathways, neuroactive ligand-receptor interaction as well as through pathways in cancer. This study provides a preliminary prediction of the mechanism of GFLZW in gastritis and offers new ideas on and a theoretical basis for further research.

Key words: network pharmacology, Gui Fu Li Zhong Pill （GFLZW）, acute gastritis （AG）, chronic gastritis （CG）, mechanism of action

中图分类号:

邱玺融, 朱朋艳, 田月, 罗言春, 解智慧. 网络药理学探究桂附理中丸治疗胃炎机制的研究[J]. 楚雄师范学院学报, 2026, 41(3): 126-143.

Qiu Xirong, Zhu Pengyan, Tian Yue, Luo Yanchun, Xie Zhihui. Research on the Mechanism of Gui Fu Li Zhong Pill in Treating Gastritis through Network Pharmacology[J]. Journal of Chuxiong Normal University, 2026, 41(3): 126-143.