Advances in the Study of Lysyl Oxidase (LOX) Family Protein and Occurrence and Development of Lung Cancer

Journal of Chuxiong Normal University ›› 2023, Vol. 38 ›› Issue (3): 70-75.

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Advances in the Study of Lysyl Oxidase (LOX) Family Protein and Occurrence and Development of Lung Cancer

WANG Boyong^1,2, LUO Zhonggui^1,2, ZHOU Chongxi^1,2, LI Bin^1,2, LIU Ruai^1,2, YANG Xi^1,2, XIONG Wei^1,2,*

1. Basic Medical College, Dali University, Dali, Yunnan Province 671000;
2. Yunnan Provincial Key Laboratory of Clinical Biochemistry, Dali, Yunnan Province 671000

Received:2022-10-05 Online:2023-05-20 Published:2023-08-07

Abstract

Abstract: The lysyl oxidase (LOX) family consists of LOX and four LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4) that act mainly in the remodeling of the extra cellular matrix (ECM) and the cross-linking of collagen and elastic fibers. As the second most common cancer worldwide, lung cancer ranks second in incidence (second only to breast cancer) and first in mortality rate. Recently, an increasing number of studies have shown that the LOX family is closely associated with the regulation of cancer cell proliferation, migration, invasion and metastasis. This review mainly presents the mechanism and research progress of each member of the LOX family in the occurrence and progression of lung cancer.

Key words: lysyl oxidase family, extracellular matrix (ECM), lung cancer, occurrence and development

CLC Number:

R734.2

WANG Boyong, LUO Zhonggui, ZHOU Chongxi, LI Bin, LIU Ruai, YANG Xi, XIONG Wei. Advances in the Study of Lysyl Oxidase (LOX) Family Protein and Occurrence and Development of Lung Cancer[J]. Journal of Chuxiong Normal University, 2023, 38(3): 70-75.

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Advances in the Study of Lysyl Oxidase (LOX) Family Protein and Occurrence and Development of Lung Cancer

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