Journal of Chuxiong Normal University ›› 2021, Vol. 36 ›› Issue (3): 60-66.

• Biology • Previous Articles     Next Articles

Evaluation of the Value of Serum Non-coding RNA SCHLAP1 Combined with PSA in the Diagnosis of Prostate Cancer

ZOU Jing1, TANG Ying2, HAN Hong1, ZHANG Cuixiang   

  1. 1. First Affiliated Hospital, Dali University, Dali, Yunnan Province 671000;
    2. Basic Medical College, Dali University, Dali, Yunnan Province 671000;
    3. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali, Yunnan Province 671000
  • Received:2020-11-11 Online:2021-05-20 Published:2021-07-23

Abstract: Objective:to explore the clinical significance of serum SCHLAP1 and prostate specific antigen (PSA) in detection of patients with prostatic cancer (PCa). Methods:A total of 30 cases of prostate cancer, 30 cases of benign prostate hyperplasia and 30 healthy controls between April 2019 and August 2018 were included in the study. Serum levels of SCHLAP1 and PSA were detected by Biotin labeling probe and RIA, then the cure of the receiver operating characteristics cure (ROC) was drawn, and test results of SCHLAP1, tPSA, fPSA and fPSA/tPSA were compared. Results:The difference of serum SCHLAP1 in patients with prostate cancer, benign prostate hyperplasia and healthy people were statistically significant (P<0.01). ROC showed that the sensitivity and specificity of SCHLAP1 alone were 76.4% and 93.6% respectively, and the sensitivity and specificity of SCHLAP1 joint tPSA detection were 92.0% and 88.3% respectively. Conclusion:The co-detection of SCHLAP1 with PSA can make up for the lack of PSA alone, and improve the accuracy of prostate cancer detection.

Key words: non-coding RNA SCHLAP1, diagnostic value, prostatic neoplasm, prostatic hyperplasia, prostate-specific antigen

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